Thermo Fisher Scientific CD66 Monoclonal Antibody (CD66a-B1.1), Alexa Fluor 488, eBioscience
인체 CD66a, c, d, e 인식 단일클론 항체로 Alexa Fluor 488에 결합되어 형광 분석에 적합. 유세포 분석용으로 검증되었으며, 5 µL/test로 사용. 세포 부착, 성장, 신호전달 연구에 활용 가능. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.25 µg)/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD66a-B1.1 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2811857 |
Additional Formats:
Product Specific Information
Description:
The CD66a-B1.1 monoclonal antibody reacts with human CD66a, c, d, and e (also known as CEACAM1, CEACAM6, CEACAM3, and CEA). CD66 is expressed on endothelial and epithelial cells, neutrophils, monocytes, and certain tumor cells. Expression can also be induced on T cells, B cells, and CD16-negative NK cells. CD66 exists as multiple splice variants with cytoplasmic ITIM domains that mediate inhibitory signaling in T and NK cells. It plays roles in cell adhesion, growth, neutrophil activation, and signaling, and can form homo- and heterotypic interactions.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-diluted and tested by flow cytometry of normal human peripheral blood cells. Recommended use: 5 µL (0.25 µg) per test in 100 µL final volume. Suitable for 10⁵–10⁸ cells/test.
Excitation / Emission: 488 nm / 519 nm
Laser: Blue Laser
Target Information
CD66 molecules are 180–200 kDa glycoproteins of the carcinoembryonic antigen (CEA) family. They are expressed on blood granulocytes and some tissue macrophages, but not on other hematopoietic cells. Expression increases upon granulocyte activation.
- Transmembrane proteins: CD66a (BGP1, CEACAM1), CD66d (CGM1, CEACAM3), CEACAM2, CEACAM4
- GPI-anchored proteins: CD66c (CEAL, NCA, CEACAM6), CD66e (CEA, CEACAM5), CEACAM7, CEACAM8
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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