Thermo Fisher Scientific CD68 Monoclonal Antibody (KP1), eBioscience
인간 CD68 단백질을 인식하는 KP1 클론의 마우스 단일클론 항체로 다양한 면역학적 분석에 사용 가능. IHC, WB, Flow Cytometry 등에서 검증됨. 고순도(>90%) 및 0.5 mg/mL 농도, PBS buffer 내 보관. 연구용 전용 제품.
- 카탈로그번호
- 14-0688-xx (3개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific CD68 Monoclonal Antibody (KP1), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | 2 |
| Immunohistochemistry (IHC) | - | 23 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL | 4 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1 µg/mL | 1 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | 9 |
| Flow Cytometry (Flow) | Assay-Dependent | 6 |
| ELISA | - | 1 |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Mass Spectrometry (MS) | - | 1 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864922 |
Product Specific Information
Description:
The KP1 antibody reacts with human CD68, a member of the sialomucin family related to lysosomal-associated membrane proteins (LAMPs) and scavenger receptors. CD68 is primarily an intracellular protein located in the late endosomal compartment, with minor expression on the surface of myeloid-derived cells such as monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, and CD34+ progenitor cells. It may play roles in antigen processing/presentation and lysosomal membrane protection. Expression has also been observed in activated T cells and subsets of B cells and fibroblasts.
Applications Reported:
Validated for flow cytometry, immunoprecipitation, western blotting, and immunohistochemistry (frozen and FFPE tissue sections).
Applications Tested:
Tested by IHC with both low and high pH antigen retrieval on FFPE tissue. Recommended concentration ≤ 1 µg/mL. Optimize dilution per assay.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein primarily expressed in lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and granulocytes. It is involved in phagocytic activity, lysosomal metabolism, and cell-pathogen interactions. CD68 expression is noted in interdigitating reticulum cells, histiocytic lymphoma, AML, and granulocytic sarcoma. Elevated CD68 levels have been found in CD34+ cells in various malignancies.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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