Thermo Fisher Scientific Phospho-FGFR1 (Tyr307) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phospho-FGFR1 (Tyr307). Validated for dot blot. Predicted cross-reactivity with chicken and mouse. Suitable for research on FGFR1 signaling and related pathways.
- 판매단위
- pk
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Applications
- Dot blot (DB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y307 of human FGFR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981105 |
Product Specific Information
This antibody is predicted to react with chicken and mouse based on sequence homology.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays a crucial role in biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic and adult stages.
Mutations or aberrations in FGFR1 are associated with several diseases, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal abnormalities involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia/lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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