Thermo Fisher Scientific Phospho-TNFR1 (Ser274) Polyclonal Antibody
인간 TNFR1 Ser274 인산화 부위에 특이적인 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제됨. 액상 형태, 0.5 mg/mL 농도, 안정적인 PBS buffer에 보존.
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Thermo Fisher Scientific Phospho-TNFR1 (Ser274) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S274 of human TNFR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2204143 |
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. TNFR1 plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, positive regulation of angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 is released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12.
Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 interact with TNFR1 and play regulatory roles in its signal transduction. Germline mutations in the extracellular domain of TNFR1 are associated with autosomal dominant periodic fever syndrome, with impaired receptor clearance thought to be a mechanism of disease.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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