Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 장기 보관 시 -20°C 권장.
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- PA521991
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 248–535 of SLC25A13 (Uniprot ID: Q9UJS0) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153758 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, mouse liver, rat liver
- Predicted reactivity: Mouse (96%), Xenopus laevis (88%), Chicken (94%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass membrane protein localized to the inner mitochondrial membrane. It is expressed in liver, pancreas, kidney, brain, heart, and placenta, functioning as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
Citrin contains three Solcar repeats and four EF-hand domains for calcium binding.
Defects in the SLC25A13 gene cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
CTLN2 is an autosomal recessive urea cycle disorder characterized by neuropsychiatric symptoms such as memory loss, seizures, and coma, while NICCD manifests in infancy with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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