Thermo Fisher Scientific LAMB2 Monoclonal Antibody (OTI3B4), TrueMAB
LAMB2 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western Blot 및 IHC(P) 검증 완료. 인간, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며 PBS/trehalose buffer 포함. 연구용으로 적합하며 carrier-free 형태로 conjugation 실험에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 314–561 of human LAMB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes exist: A-type and B-type lamins.
A-type lamins (lamin A, lamin C, lamin Adel 10) arise from alternative splicing of a single gene, while B-type lamins (lamin B1, lamin B2) derive from distinct genes.
Mutations in A-type lamins are associated with rare dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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