Thermo Fisher Scientific TRIM56 Monoclonal Antibody (OTI5A1), TrueMAB
TRIM56 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Human 시료 반응성, Lyophilized 형태로 제공되며, PBS buffer(8% trehalose)로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 311–554 of human TRIM56 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TRIM56 is an E3 ubiquitin-protein ligase involved in innate antiviral immunity.
In response to pathogen- or host-derived double-stranded DNA (dsDNA), it targets STING1 for Lys-63-linked ubiquitination, promoting homodimerization and type I interferon (IFN-β) production.
Independently of its ligase activity, TRIM56 acts as a positive regulator of TLR3 signaling, enhancing dsRNA-induced expression of IFNB1 and interferon-stimulated genes (ISG15, IFIT1/ISG56, CXCL10, OASL, CCL5/RANTES).
It contributes to antiviral state establishment and chemokine induction following hepatitis C virus infection.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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