Thermo Fisher Scientific GATM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, chicken, mouse, porcine, non-human primate, rat, and zebrafish based on sequence homology.

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family.
Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure.

AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm. It is biallelically expressed in placenta and fetal tissues, and also expressed in brain, heart, liver, lung, salivary gland, and skeletal muscle tissue, with high expression in kidney.
AGAT is elevated in the myocardium during heart failure and decreased in inter-uterine growth restriction (IUGR)-associated placenta.

AGAT catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in brain.
AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 – OCR 텍스트만 통합됨)