Thermo Fisher Scientific Pan Ras Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:300

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total RASH/RASK/RASN.

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, characterized by prenatal overgrowth, postnatal growth deficiency, tumor predisposition, mental retardation, and various abnormalities. Defects in this gene are implicated in cancers such as bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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