Thermo Fisher Scientific MYH9 Polyclonal Antibody
Thermo Fisher Scientific MYH9 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Western Blot, IHC, ICC 등 다양한 응용에 적합합니다. Rabbit IgG 기반의 비결합 항체로, 항원 친화 크로마토그래피로 정제되었습니다. 세포골격 및 MYH9 관련 질환 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
| Immunoprecipitation (IP) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–170 of Human MYH9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2547148 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, NIH-3T3, BCL-1, Raw264.7, C2C12, Rat2
- Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (91%), Dog (99%), Chicken (95%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton. It is essential for cellular processes such as migration, adhesion, division, and maintenance of cell shape.
Mutations in MYH9 cause autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These disorders are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a key role in hematopoiesis, maintaining hematopoietic stem and progenitor cells. Loss of MYH9 function can result in severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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