Thermo Fisher Scientific CD59 Monoclonal Antibody (1F5), FITC
CD59 단백질을 표적하는 FITC 결합 단클론 항체로, 인간 및 마우스 시료에 반응. Flow Cytometry(FACS) 분석에 적합. 단백질 G로 정제된 액상 형태이며, 단기 4°C·장기 -20°C 보관 가능. 연구용으로만 사용.
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Applications
- Flow Cytometry (Flow): Tested at 1.0 µg/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F5 |
| Immunogen | Neuraminidase-treated Human Erythrocytes (Neu-HuE) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles; store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539128 |
Additional Formats
- Unconjugated (MA1-70058)
- Biotin (MA5-17737)
- PE (MA5-17739)
- Custom conjugation available upon request
Product Specific Information
MA5-17738 targets CD59/Protectin in FACS applications and shows reactivity with Human samples.
The MA5-17738 immunogen is mouse pre-B tumour cells (RAW112).
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC).
It regulates complement cascade by preventing formation of cytolytic pores in the plasma membrane.
CD59 also interacts with C5b-8 complex and inhibits incorporation of C9, essential for pore formation.
It acts as a low-affinity ligand of human CD2, contributing to T cell costimulation and lymphocyte signaling.
Mutations in CD59 cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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