Thermo Fisher Scientific Nitrotyrosine Monoclonal Antibody (HM11)

Thermo Fisher Scientific Nitrotyrosine Monoclonal Antibody (HM11)

Applications and Tested Dilutions

Product Specifications

Target Information

Nitrotyrosine is a relatively stable product formed from various reaction pathways. Most notably, it results from the reaction of peroxynitrite (formed from superoxide and nitric oxide radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins, leading to inactivation of certain enzymes such as alpha1-antiproteinase, catalase, and superoxide dismutase (SOD).

Nitrotyrosine serves as an indicator of cell damage and inflammation, as well as nitric oxide (NO) production. Measuring its concentration can act as a marker for NO-induced cellular damage. It has been implicated in the pathogenesis of multiple inflammatory, infectious, and degenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, and atherosclerosis.

At the protein level, tyrosine nitration can alter or inhibit protein function, as demonstrated for oncogenic protein p53 and mitochondrial protein manganese-dependent superoxide dismutase (MnSOD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.