Thermo Fisher Scientific PRRX2 Polyclonal Antibody
PRRX2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot 및 IHC에 사용 가능하며, 인간 시료에 반응. 합성 펩타이드 항원으로 제작되었으며, 고순도의 액상 형태로 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human PRRX2 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2605827 |
Product Specific Information
Peptide sequence:
RKNFSVSHLL DLEEVAAAGR LAARPGARAE AREGAAREPS GGSSGSEAAP
Sequence homology:
Cow: 79%
Dog: 79%
Guinea Pig: 79%
Horse: 79%
Human: 100%
Mouse: 79%
Pig: 93%
Rabbit: 79%
Rat: 79%
Zebrafish: 79%
Target Information
The paired-class homeobox genes PRX1 and PRX2 are essential for craniofacial and limb development, expressed in cranial mesenchyme, limb buds, axial mesoderm, and branchial arches.
PRX1 is expressed in endocardial cushions and cardiac valves, while PRX2 shows myocardial and ventricular septum expression. PRX2 is not expressed in the brain, unlike PRX1.
Murine models lacking PRX1 exhibit skeletal defects, whereas PRX2 deficiency alone shows no abnormalities. However, PRX1/PRX2 double mutants present unique skeletal abnormalities.
PRX gene expression can be induced in vascular disease where it co-localizes with Tenascin-C expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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