Thermo Fisher Scientific SMAD2 Polyclonal Antibody
SMAD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종(Human, Mouse, Rat)에 반응하며 WB, IHC, ELISA 등 여러 응용 분야에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용에 적합.
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Thermo Fisher Scientific SMAD2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | 54 publications |
| Immunohistochemistry (IHC) | – | 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 1 publication |
| Immunocytochemistry (ICC/IF) | – | 5 publications |
| ELISA | 0.1–1.0 µg/mL | 1 publication |
| Immunoprecipitation (IP) | – | 3 publications |
| ChIP assay (ChIP) | 1–3 µg × 10⁶ cells | 6 publications |
| Miscellaneous PubMed (Misc) | – | 4 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Dog, Human, Luciferase, Mouse, Non-human primate, Rat, Tag, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 27 amino acid synthetic peptide derived from the MH1 domain of human Smad2. Shares 24/27 residues with mouse Smad2 and 26/27 residues with Xenopus Smad2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533896 |
Target Information
SMAD2 (MADH2, MAD2) regulates multiple cellular processes such as cell proliferation, apoptosis, and differentiation. It interacts with TGF-beta receptors via SMAD anchor for receptor activation, playing a central role in TGF-beta signaling. Phosphorylation of threonine 8 by ERK1 enhances SMAD2 transcriptional activity, negatively regulated by calmodulin. Upon TGF-beta stimulation, SMAD2 is phosphorylated, dissociates from SARA, and associates with SMAD4, enabling nuclear translocation and transcriptional repression. SMAD2 can also be phosphorylated by activin type 1 receptor kinase and mediates activin signaling. Alternative splicing variants encoding SMAD2 have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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