Thermo Fisher Scientific CDH11 Monoclonal Antibody (16A6)

Applications

• Western Blot (WB): 1:100
• Immunoprecipitation (IP): Assay-dependent

Product Specifications

Target Information

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type II cadherins include human cadherin-5, -6, -8, -11, and -12, defined by their lack of a HAV cell adhesion recognition sequence specific to type I cadherins.

Cadherin-11 (OB-Cadherin) is a marker of loosely connected and migratory mesenchymal cells. Strong expression is observed in brain, spinal cord, bone marrow, and bone cells, and regulated in human endometrial glandular epithelial and stromal cells. Its expression in osteoblastic cell lines and upregulation during differentiation suggest a role in bone development and maintenance. A variant Cadherin-11 gene encodes a truncated protein with an unusual cytoplasmic domain produced via alternative splicing. Cadherin-11 mRNA and protein are expressed in most invasive breast cancer cell lines but not in non-invasive ones, indicating its potential as a marker for aggressive, invasive tumor subsets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.