Thermo Fisher Scientific CDH11 Monoclonal Antibody (16G5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This target has a predicted molecular weight of 87 kDa.

Target Information

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain.

Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type II cadherins include human cadherin-5, -6, -8, -11, and -12, characterized by the lack of a HAV cell adhesion recognition sequence found in type I cadherins.

Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow, and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression in osteoblastic cell lines and its upregulation during differentiation suggest a role in bone development and maintenance.

A variant Cadherin-11 gene encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins, generated by alternative splicing utilizing a 179 bp intronic sequence. Cadherin-11 mRNA and protein are expressed in most invasive breast cancer cell lines but not in non-invasive ones, suggesting its potential as a marker for aggressive, invasive tumor subsets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.