Thermo Fisher Scientific CPSF1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
AISLNITQKVH PVIWSLTSLP FDCTQALAVP KPIGGVVVFA VNSLLYLNQS VPPYGVALNS LTTGTTAFPL RT

Highest antigen sequence identity to the following orthologs:

• Mouse: 99%
• Rat: 99%

Target Information

Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1.
Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain, and one RING-type zinc finger.
It is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation.
This cytoplasmic protein is found as a homodimer or heterodimer with Midline-2 and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 are the cause of Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genitourinary defects, cleft lip/palate, imperforate anus, developmental delay, and congenital heart defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.