Thermo Fisher Scientific FIG4 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human FIG4

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664269

Product Specific Information

Immunogen sequence: VKEREKRKHER ILSEELVAAV TYLNQFLPPE HTIVYIPWDM AKYTKSKLCN VLDRLNVIAE SVVKKTGFFV NRPDSYCSIL RPDEKWNELG GCVIPTGR

Highest antigen sequence identity to the following orthologs - mouse 99%, rat 97%.

Target Information

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.