Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDK2AP1 for ICC/IF applications. Antigen affinity purified and supplied in PBS with glycerol. Suitable for research on cell cycle and epigenetic regulation. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CDK2AP1. Recombinant protein control fragment (Product # RP-107659) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662026 |
Product Specific Information
Immunogen sequence:
MSYKPNLAAHM PAAALNAAGS VHSPSTSMA
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 93%
Target Information
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2 and targeting it for proteolysis. It also interacts with DNA polymerase alpha/primase and mediates phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during the S-phase of the cell cycle. Additionally, it forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation. Thus, this gene plays roles in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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