Thermo Fisher Scientific CRX Polyclonal Antibody
CRX 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA에 적용 가능. 고순도 Affinity Chromatography 정제, 2.35 mg/mL 농도. 시각 관련 유전자 연구 및 광수용체 발현 분석에 적합.
- 카탈로그번호
- PA5109592
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 100–200 of human CRX (NP_0005451) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855003 |
Product Specific Information
Immunogen sequence:
QQKQQQQPPG GQAKARPAKR KAGTSPRPST DVCPDPLGIS DSYSPPLPGP SGSPTTAVAT VSIWSPASES PLPEAQRAGL VASGPSLTSA PYAMTYAPAS A
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controlling the expression of melatonin synthesis genes.
CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in visual pathologies such as CORD, Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes, with no known correlation between phenotype and mutation type. Missense mutations affect the homeobox domain, while frameshift mutations affect the OTX domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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