Thermo Fisher Scientific CRX Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
QQKQQQQPPG GQAKARPAKR KAGTSPRPST DVCPDPLGIS DSYSPPLPGP SGSPTTAVAT VSIWSPASES PLPEAQRAGL VASGPSLTSA PYAMTYAPAS A

Target Information

The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controlling the expression of melatonin synthesis genes.

CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in visual pathologies such as CORD, Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes, with no known correlation between phenotype and mutation type. Missense mutations affect the homeobox domain, while frameshift mutations affect the OTX domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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