Thermo Fisher Scientific Arginase 1 Recombinant Rabbit Monoclonal Antibody (BLR036F)

Applications and Tested Dilutions

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 reduces nitric oxide production by limiting substrate availability for NO synthase.
In both humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, it is found in blood neutrophils but not in CCR3+ granulocytes. In mice, it is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may be expressed in myeloid cells infiltrating tumors and is commonly detected in hepatocellular carcinomas. Defects in the Arginase 1 gene cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.