Thermo Fisher Scientific VISTA Recombinant Rabbit Monoclonal Antibody (BLR035F)
VISTA 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등 다양한 응용에 적합합니다. HEK293F 발현 시스템에서 생산되며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR035F |
| Immunogen | Peptide representing a region between residue 250 and the C-terminus (residue 311) of Human V-type immunoglobulin domain-containing suppressor of T-cell activation precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is encoded by the VSIR gene.
Although VISTA shares sequence homology with PD-L1, it exhibits a distinct expression pattern. In both mouse and human, VISTA is predominantly expressed on hematopoietic cells, with the highest levels on myeloid cells and lower levels on T cells, while typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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