Thermo Fisher Scientific Aldolase Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot contents and freeze at -20°C or below.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-goat serum, purified and partially purified Aldolase [Rabbit Muscle].
This antibody will detect human Aldolase. Cross-reactivity against Aldolase from other tissues and species may also occur.
It has been reported that this antibody can detect human Aldolase on immunoblot showing a 41 kDa band in lysates from MCF7, NMB231, and HBL100 cell lines.

Target Information

Aldolase encodes a member of the class I fructose-bisphosphate aldolase protein family.
This glycolytic enzyme catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.
Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development.
Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia.
Disruption of this gene also plays a role in the progression of multiple types of cancers.
Related pseudogenes have been identified on chromosomes 3 and 10.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.