Thermo Fisher Scientific SCNN1B Polyclonal Antibody
SCNN1B 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. 토끼 IgG 호스트, Protein A 정제, 1 mg/mL 농도. 인간, 설치류 등 다양한 종에 반응하며 연구용으로 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SCNN1B Polyclonal Antibody
Thermo Fisher Scientific SCNN1B Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Produced against the C-terminal tail (amino acids 617–638) of rat beta ENaC (antibody designation 3755-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736576 |
Product Specific Information
1 µg/mL of PA5-77817 was sufficient for detection of beta-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 87 kDa.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
The channel forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease due to unresponsiveness to mineralocorticoids. PHA1 presents in neonates with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, and failure to thrive.
Defects in SCNN1B also cause Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.