Thermo Fisher Scientific SCNN1B Polyclonal Antibody

Thermo Fisher Scientific SCNN1B Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

1 µg/mL of PA5-77817 was sufficient for detection of beta-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 87 kDa.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.

The channel forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease due to unresponsiveness to mineralocorticoids. PHA1 presents in neonates with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, and failure to thrive.
Defects in SCNN1B also cause Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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