Thermo Fisher Scientific Phospho-alpha Synuclein (Ser129) Polyclonal Antibody
Phospho-alpha Synuclein (Ser129)에 특이적으로 결합하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Human, Mouse, Rat 반응성. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Alpha Synuclein의 Ser129 인산화 형태만 검출.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of Human Alpha Synuclein pSer129 (40–140 aa), conjugated to Keyhole Limpet Haemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736285 |
Product Specific Information
- 1:1,000 dilution of PA5-77815 detects Alpha Synuclein pSer129 in 15 µg human brain lysates by ECL immunoblot using goat anti-rabbit IgG:HRP secondary antibody.
- Specifically binds to phosphorylated serine 129 on alpha synuclein.
- Does not detect unphosphorylated serine 129 alpha synuclein.
- Detects bands at 100, 75, 45, and 15 kDa (bands above 15 kDa are oligomers).
Target Information
Alpha-synuclein is a member of the synuclein family, including beta- and gamma-synuclein. These proteins are abundant in the brain and regulate synaptic transmission and membrane trafficking.
Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease.
Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease brains.
Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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