Thermo Fisher Scientific FGFR-3 Polyclonal Antibody
FGFR-3 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. Western blot 및 Immunohistochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 안정화제가 포함된 PBS에 보관됩니다.
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Thermo Fisher Scientific FGFR-3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1–5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 14aa synthetic peptide derived from aa 359–372 of human FGFR-3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma and umbilical cord
- Cellular location: Cell membrane
Target Information
FGFR3 (Fibroblast Growth Factor Receptor 3) is a receptor tyrosine kinase involved in various cellular processes including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair. FGFR family members differ in ligand affinity and tissue distribution. The full-length protein includes:
- Extracellular region with three immunoglobulin-like domains
- Single hydrophobic membrane-spanning segment
- Cytoplasmic tyrosine kinase domain
FGFR3 interacts with fibroblast growth factors, activating downstream signaling pathways that regulate cell growth and differentiation. It plays a crucial role in bone development and maintenance. Mutations in FGFR3 are associated with craniosynostosis and multiple skeletal dysplasias. Three alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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