Thermo Fisher Scientific Vasopressin V1b Receptor Polyclonal Antibody
Vasopressin V1b 수용체를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. Western blot에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- 500-10214
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Vasopressin V1b Receptor Polyclonal Antibody
Applications
- Western Blot (WB): 0.1–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the extracellular domain of V1b vasopressin receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse pituitary tissue
- Cellular location: Cell membrane
Target Information
Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This turn-off activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two blockbuster drugs developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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