Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37)
Ataxin 1 단백질 검출용 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone N65/37). Western blot 및 Immunocytochemistry에 적합하며 Human, Mouse, Rat 반응성. 고순도 Protein G 정제, -20°C 보관, 연구용 전용.
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Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N65/37 |
| Immunogen | Synthetic peptide amino acids 746–761 (RKRRWSAPETRKLEKS) of mouse ataxin-1. Rat: 93% identity (15/16 amino acids identical). Human: 87% identity (14/16 amino acids identical). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735119 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-27667 was sufficient for detection of Ataxin 1 in 20 µg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 85 kDa.
No cross-reactivity against phosphor S751-Ataxin-1. Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot.
This antibody was formerly sold as clone S65-37.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci (SCA1, 2, 3, 4, and 6) assigned to different chromosomes. ADCAII presents with retinal degeneration (SCA7), and ADCAIII, often referred to as the ‘pure’ cerebellar syndrome (SCA5), is likely homogeneous.
ADCA is caused by expansion of CAG repeats, producing elongated polyglutamine tracts in the corresponding protein. The diseased allele contains 41–81 CAG repeats compared to 6–39 in normal alleles and is associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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