Thermo Fisher Scientific ABHD13 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite having unrelated sequences and substrates, they share a canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad composed of histidine, acid, and nucleophile residues.

Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders. The ABHD gene subfamily includes 15 mostly uncharacterized members, most of which use a serine nucleophile to form the G-X-S-X-G nucleophile elbow.

• ABHD1: Involved in metabolizing smoking xenobiotics
• ABHD2: Participates in atherosclerosis development
• ABHD4: Involved in an alternative synthesis pathway of NAE
• ABHD5: Mutations contribute to Chanarin-Dorfman syndrome
• ABDH6: May play a role in nervous system metabolism and signaling
• ABHD13: A 337 amino acid single-pass membrane protein belonging to the ABHD family

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.