Thermo Fisher Scientific Axonal Growth Cones Monoclonal Antibody (2G13)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

-

Product Specifications

Species Reactivity

Chicken, Mouse, Rat

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

2G13

Immunogen

Embryonic chick tectal membranes.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant with 5-10% FBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_927085

Product Specific Information

This product does not require protein digestion pre-treatment of paraffin embedded sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin embedded sections.

Mouse anti Growth Cone antibody, clone 2G13 recognizes a protein originally termed 2G13P which is localized to growth cones.

Target Information

This protein was originally termed 2G13P, which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or Laminin receptor 1 (Baloui et al. 2004). 40S ribosomal protein SA is a 296 amino acid ~37kDa membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor (UniProt: P50890). In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture (Stettler et al. 1999). 40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility (Stettler et al. 1999).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.