Thermo Fisher Scientific HDAC9 Polyclonal Antibody
HDAC9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 사람, 마우스, 개, 소 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 용액 내 0.02% sodium azide를 포함하고 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Non-human primate |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 100–150 of human HDAC9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540870 |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, and acetylation of nucleosomal histones is a major mechanism in this process. Acetylation of lysine residues in histone tails induces conformational changes that increase DNA accessibility to transcription factors.
Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and TFIID subunit TAF II p250. Conversely, histone deacetylation is associated with transcriptional silencing. The histone deacetylases (HDAC) family includes HDAC1–9. HDAC9 and HDAC9a are alternatively spliced isoforms; HDAC9a is 132 amino acids shorter but retains catalytic activity and represses myocyte enhancer-binding factor 2-mediated transcription. Both isoforms are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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