Thermo Fisher Scientific HEXA/Beta hexosaminidase subunit alpha Polyclonal Antibody
Rabbit polyclonal antibody against human Beta hexosaminidase subunit alpha (HEXA). 검증된 IHC, ICC, ELISA 적용 가능. 고순도 액상형(1 mg/mL), -20°C 보관. Tay-Sachs 관련 연구 등 GM2 gangliosidosis 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Beta hexosaminidase subunit alpha (amino acids 351–420) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase, which, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines.
Beta-hexosaminidase consists of two subunits (alpha and beta), encoded by separate genes. Both subunits belong to glycosyl hydrolase family 20.
Mutations in either gene cause accumulation of GM2 ganglioside in neurons, leading to GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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