Thermo Fisher Scientific SREBP1 Monoclonal Antibody (2A4)
SREBP1 단백질 검출용 Thermo Fisher monoclonal antibody (clone 2A4). Western blot, IHC, Flow Cytometry에 사용 가능. 다양한 종(인간, 마우스, 랫 등)에 반응. 고순도 Protein G 정제, 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 22 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Flow Cytometry (Flow) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Hamster, Human, Mouse, Rat |
| Published Species | Avian, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A4 |
| Immunogen | 6 His-tag fusion protein of SREBP1 (amino acids 301–407) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152118 |
Product Specific Information
- In Western blot, a band can be seen at 125 kDa (precursor) and additional bands may appear at 60–70 kDa (cleaved forms).
- Suggested positive control: IMR-5 and HeLa cells.
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins.
Three isoforms have been identified in mammalian tissues (SREBP-1a, SREBP-1c, and SREBP-2), differing in structure, regulation, and function.
SREBPs exist as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, they translocate to the Golgi, undergo proteolytic cleavage, and yield a mature transcriptionally active 60–78 kDa fragment.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol accumulation by inducing transcription of related genes.
SREBP-1 mainly controls triglyceride synthesis, while SREBP-2 is associated with cholesterol synthesis and accumulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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