Thermo Fisher Scientific KIDINS220 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KIDINS220 protein. Validated for Western blot applications. Supplied as a liquid, unconjugated form with 1 mg/mL concentration. Suitable for neuroscience research on neuronal signaling and synaptic plasticity.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of human Kidins220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2296526 |
Product Specific Information
PA1-4229 detects the Kidins220 protein in human samples and has been successfully used in Western blot procedures.
The immunogen is a synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of the human 220 kDa Kidins220 protein.
Target Information
The KIDINS220 gene encodes a transmembrane protein preferentially expressed in the nervous system. It regulates neuronal cell survival, differentiation into axons and dendrites, and synaptic plasticity. The protein acts as a scaffold mediating crosstalk between the neurotrophin pathway and other intracellular signaling pathways.
Aberrant expression is linked to neuropsychiatric and neurodegenerative disorders, including Alzheimer’s disease. Mutations in this gene are associated with a syndrome featuring spastic paraplegia, intellectual disability, nystagmus, and obesity. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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