Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide shares 87% identity with mouse and human sequences.
• Specificity: Huntingtin.

Target Information

Huntingtin is the gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, resulting in a polyglutamine repeat in the protein product. HD is an autosomal dominant disorder with mid-life onset, presenting with psychiatric symptoms, dementia, and involuntary movements (chorea), leading to death within 10–20 years.

The huntingtin locus spans 180 kb and consists of 67 exons. It is widely expressed and required for normal development. Two alternatively polyadenylated transcripts (13.7 kb and 10.3 kb) show tissue-specific expression patterns. The pathogenic mutation may not abolish transcription but instead alter mRNA or protein function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.