Thermo Fisher Scientific Huntingtin Polyclonal Antibody
Huntingtin 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 사용 가능. Mouse, Rat 반응성. 합성 펩타이드(aa 1150-1200)로 면역화됨. Lyophilized 형태로 제공되며 PBS buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 1150–1200 of rat Huntingtin conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C short term; for long term, store at −20 °C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide shares 87% identity with mouse and human sequences.
- Specificity: Huntingtin.
Target Information
Huntingtin is the gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, resulting in a polyglutamine repeat in the protein product. HD is an autosomal dominant disorder with mid-life onset, presenting with psychiatric symptoms, dementia, and involuntary movements (chorea), leading to death within 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. It is widely expressed and required for normal development. Two alternatively polyadenylated transcripts (13.7 kb and 10.3 kb) show tissue-specific expression patterns. The pathogenic mutation may not abolish transcription but instead alter mRNA or protein function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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