Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide shares 87% identity with mouse and human sequences.
• Specificity: Huntingtin.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein. HD is an autosomal dominant disorder with mid-life onset, leading to psychiatric symptoms, dementia, and involuntary movements (chorea), typically resulting in death within 10–20 years.

The huntingtin locus spans 180 kb with 67 exons. The gene is widely expressed and essential for normal development. It produces two alternatively polyadenylated transcripts (13.7 kb and 10.3 kb) with differing tissue expression patterns. The larger transcript is mainly expressed in brain tissue, while the smaller transcript is more broadly distributed. The genetic defect may alter mRNA or protein function rather than eliminating transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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