Thermo Fisher Scientific Huntingtin Polyclonal Antibody
Thermo Fisher Scientific의 Huntingtin Polyclonal Antibody는 Huntington 단백질을 검출하기 위한 연구용 항체로, WB, IHC, ICC/IF에 사용 가능하며 마우스와 랫트에 반응합니다. 합성 펩타이드 면역원 기반으로 제작되었고, 동결건조 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:500 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 1150–1200 of rat Huntingtin conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide shares 87% identity with mouse and human sequences.
- Specificity: Huntingtin.
Target Information
Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein. HD is an autosomal dominant disorder with mid-life onset, leading to psychiatric symptoms, dementia, and involuntary movements (chorea), typically resulting in death within 10–20 years.
The huntingtin locus spans 180 kb with 67 exons. The gene is widely expressed and essential for normal development. It produces two alternatively polyadenylated transcripts (13.7 kb and 10.3 kb) with differing tissue expression patterns. The larger transcript is mainly expressed in brain tissue, while the smaller transcript is more broadly distributed. The genetic defect may alter mRNA or protein function rather than eliminating transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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