Thermo Fisher Scientific GATM Monoclonal Antibody (OTI1E3), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family.
Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure.
AGAT localizes to mitochondrial inner membranes, peripheral membranes and cytoplasm.
It is expressed in placenta, fetal tissues, brain, heart, liver, lung, salivary gland and skeletal muscle, with high expression in kidney.
AGAT is elevated in the myocardium during heart failure and decreased in IUGR-associated placenta.
AGAT catalyzes biosynthesis of guanidinoacetate, the precursor of creatine, crucial for muscle energy metabolism.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, and severe depletion of brain creatine/phosphocreatine.
AGAT may be linked to embryonic and central nervous system development and may function in heart failure response via local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.