Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI2F1), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where its expression is often reduced or undetectable.
The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder associated with CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between ACY1 and the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.