Thermo Fisher Scientific Human FGF-basic (FGF-2/bFGF) (154 aa) Recombinant Protein, PeproTech
인간 FGF-basic (bFGF/FGF-2) 재조합 단백질로, 세포 증식 및 신생혈관 형성을 촉진합니다. E. coli 발현 시스템에서 생산되었으며, 순도 ≥95%, 엔도톡신 <1 EU/µg 수준입니다. 줄기세포 연구에 적합하며, -20°C에서 보관합니다.
- 카탈로그번호
- 100-18B-xxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human FGF-basic (FGF-2/bFGF) (154 aa) Recombinant Protein, PeproTech
Applications and Publications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | 3 |
| ELISA | Assay-dependent | 2 |
| Immunoprecipitation (IP) | - | 1 |
| Functional Assay | Assay-dependent | - |
| Radioimmune Assays (RIA) | - | 1 |
| Control (Ctrl) | - | 1 |
| In vitro Assay (IV) | - | 1,419 |
| Miscellaneous PubMed (Misc) | - | 207 |
| Immunostaining (IS) | - | 1 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Amphibian, Avian, Bacteria, Bovine, Camelid, Cat, Chicken, Cynomolgus monkey, Dog, Fish, Guinea pig, Hamster, Horse, Human, Mammal, Mouse, Non-human primate, Panda, Pig, Rabbit, Rat, Sheep, Virus |
| Expression System | E. coli |
| Amino Acid Sequence | AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS |
| Molecular Weight | 17.2 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% (SDS-PAGE and HPLC) |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Cell proliferation assay using Balb/c 3T3 cells; ED50 ≤ 0.1 ng/ml (≥ 1×10⁷ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.
Qualified for stem cell use.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms (18, 22, 22.5, 24, and 34 kDa) with distinct intracellular localizations and functions. The 18 kDa isoform is cytosolic and acts through cell surface receptors, while the others are nuclear and may signal independently.
In humans, the gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth.
Multiple polyadenylation sites and alternative translation from non-AUG/AUG codons result in isoforms with unique properties.
CUG-initiated forms are nuclear (intracrine effect), and AUG-initiated forms are cytosolic (paracrine/autocrine effects).
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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