Thermo Fisher Scientific SAP102 Polyclonal Antibody

Thermo Fisher Scientific SAP102 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:400

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL or 0.2 mL double distilled water (DDW), depending on sample size.
• Ships as a lyophilized powder at room temperature.
• Store upon arrival at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid repeated freeze/thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Synapse-Associated Protein 102 (SAP102) is a plasma membrane-associated protein found in synaptic junctions. It contains three PDZ domains, an SH3 domain, and a Guanylate Kinase (GuK) domain.
PDZ-domain interactions are thought to contribute to receptor and channel clustering, influencing neuronal plasticity.
SAP102 interacts with NMDA receptors and shaker-type potassium channels at synaptic membranes.
Other neuronal proteins with similar motifs (such as β1 adrenergic receptors, serotonin receptors, sodium channel subunits, and potassium channel subunits) may also bind to SAP102 via PDZ domains.
Neuronal nitric oxide synthase (nNOS) can associate with SAP102 through PDZ-PDZ interactions.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.