Thermo Fisher Scientific Caspr2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

This gene encodes a member of the neurexin family functioning in the vertebrate nervous system as a cell adhesion molecule and receptor.
Caspr2 contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.
Localized at the juxtaparanodes of myelinated axons, Caspr2 mediates neuron-glia interactions during nervous system development and assists in potassium channel localization within differentiating axons.
This gene covers nearly 1.5% of chromosome 7, one of the largest in the human genome, and is directly regulated by FOXP2, a transcription factor linked to speech and language development.
Mutations or dysregulation of Caspr2 have been associated with neurodevelopmental disorders such as Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and intellectual disability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.