Thermo Fisher Scientific PSMD7 Polyclonal Antibody
PSMD7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 사람, 마우스, 랫트 시료에 반응하며 1 mg/mL 농도의 액상 형태입니다. 친화 크로마토그래피로 정제되었으며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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- PA5144642
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:600 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human PSMD7 aa 1–200/324 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093615 |
Product Specific Information
- Positive control: K562 cell lysate, mouse testis tissue lysate, HeLa cell lysate, rat testis tissue lysate, rat brain tissue, human colon tissue
- Predicted band size: 37 kDa
- Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus
Target Information
Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channel regulation, cell cycle, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins in eukaryotic cells, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31 subunits), barrel-shaped complex (~2.5 MDa) composed of a 20S core particle capped by one or two 19S regulatory complexes. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core for degradation.
Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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