Thermo Fisher Scientific PSMD7 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: K562 cell lysate, mouse testis tissue lysate, HeLa cell lysate, rat testis tissue lysate, rat brain tissue, human colon tissue
• Predicted band size: 37 kDa
• Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channel regulation, cell cycle, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins in eukaryotic cells, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31 subunits), barrel-shaped complex (~2.5 MDa) composed of a 20S core particle capped by one or two 19S regulatory complexes. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core for degradation.
Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.