Thermo Fisher Scientific PSMB6 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Hela cell lysate, Jurkat cell lysate, mouse colon tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, NIH/3T3, mouse brain tissue, Hela.
• Predicted band size: 25 kDa
• Subcellular Location: Cytoplasm, Nucleus

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while other proteins are degraded via the vacuolar pathway (endosomes, lysosomes, endoplasmic reticulum).

The 26S proteasome is an ATP-dependent, multisubunit (~31) complex (~2.5 MDa) consisting of a 20S proteolytic core and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and mediate unfolding and translocation into the 20S core.
The PA28/11S REG Activator complex (alpha, beta, gamma subunits) enhances 20S proteolytic activity.

Defects in the ubiquitin-proteasome pathway are linked to genetic diseases such as cystic fibrosis, Angelman syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.