Thermo Fisher Scientific PSMB6 Polyclonal Antibody
PSMB6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. 높은 특이성과 재현성을 제공하며, Human, Mouse, Rat 시료에 반응. 연구용으로 단백질 분해 및 유비퀴틴-프로테아좀 경로 연구에 활용 가능.
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- PA5144637
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human Proteasome 20S beta 6 aa 21–239/239 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3094037 |
Product Specific Information
- Positive control: Hela cell lysate, Jurkat cell lysate, mouse colon tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, NIH/3T3, mouse brain tissue, Hela.
- Predicted band size: 25 kDa
- Subcellular Location: Cytoplasm, Nucleus
Target Information
Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while other proteins are degraded via the vacuolar pathway (endosomes, lysosomes, endoplasmic reticulum).
The 26S proteasome is an ATP-dependent, multisubunit (~31) complex (~2.5 MDa) consisting of a 20S proteolytic core and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and mediate unfolding and translocation into the 20S core.
The PA28/11S REG Activator complex (alpha, beta, gamma subunits) enhances 20S proteolytic activity.
Defects in the ubiquitin-proteasome pathway are linked to genetic diseases such as cystic fibrosis, Angelman syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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