Thermo Fisher Scientific c-Mpl Polyclonal Antibody
Thermo Fisher Scientific의 c-Mpl Polyclonal Antibody는 인간 단백질에 반응하는 토끼 IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 세포막 및 골지체 위치 검출에 적합하며 연구용으로 제공됩니다.
- 카탈로그번호
- PA5144648
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human MPL aa 551–600/635 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092227 |
Product Specific Information
- Positive control: A549 cell lysate, Raji cell lysate, THP-1 cell lysate, SH-SY5Y, human placenta tissue
- Predicted band size: 71 kDa
- Subcellular Location: Cell membrane, Golgi apparatus, Cell surface
Target Information
In 1990, the oncogene v-mpl was identified from the murine myeloproliferative leukemia virus, capable of immortalizing bone marrow hematopoietic cells from various lineages. In 1992, the human homologue c-mpl was cloned, encoding a protein homologous to the hematopoietic receptor superfamily. Anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.
The ligand for c-mpl, thrombopoietin, cloned in 1994, was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The c-mpl gene product CD110 is a 635 amino acid transmembrane protein with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs.
TPO-R deficient mice exhibit severe thrombocytopenia, emphasizing the key role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon thrombopoietin binding, CD110 dimerizes, leading to phosphorylation of JAK, STAT, MAPK family kinases, adaptor protein Shc, and the receptor itself.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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