Thermo Fisher Scientific Catenin alpha-1 Polyclonal Antibody
Catenin alpha-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적인 저장 및 운송 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 167–290 of human CTNNA2 (NP_0012695261) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.22 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806030 |
Product Specific Information
Immunogen sequence:
TNEQDLANRF KEFGKEMVKL NYVAARRQQE LKDPHCRDEM AAARGALKKN ATMLYTASQA FLRHPDVAAT RANRDYVFKQ VQEAIAGISN AAQATSPTDE AKGHTGIGEL AAALNEFDNK IILD
Positive Samples: Mouse brain, Rat brain
Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, axon, cytoskeleton
Target Information
Catenin alpha-1 associates with the cytoplasmic domain of various cadherins. The catenin-cadherin complex links to the actin filament network, playing a key role in cell adhesion. It can associate with both E- and N-cadherins. While previously thought to mediate direct linkage to F-actin, newer evidence suggests CTNNA1 does not bind F-actin in the complex, indicating a distinct mechanism of actin interaction. The homodimeric form may regulate actin filament assembly and inhibit branching by competing with the Arp2/3 complex. It is crucial in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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