Thermo Fisher Scientific Connexin 31 Polyclonal Antibody

Thermo Fisher Scientific Connexin 31 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody reacts with the ~32 kDa mouse Connexin 31 on Western blots; the band observed at ~62 kDa is probably due to dimerization of Connexin 31. Several higher bands of unknown origin are observed in western blots of mouse skin homogenates.

Target Information

Gap junctions are conduits that allow direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, mediating intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.
Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.