Thermo Fisher Scientific Connexin 31 Polyclonal Antibody
Connexin 31 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 적합하며 Human 및 Mouse 시료 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 형태로 안정적 보관 가능.
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Thermo Fisher Scientific Connexin 31 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–3 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 3 publications |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of mouse Connexin 31 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533265 |
Product Specific Information
This antibody reacts with the ~32 kDa mouse Connexin 31 on Western blots; the band observed at ~62 kDa is probably due to dimerization of Connexin 31. Several higher bands of unknown origin are observed in western blots of mouse skin homogenates.
Target Information
Gap junctions are conduits that allow direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, mediating intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.
Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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