Thermo Fisher Scientific Factor X/Xa Recombinant Rabbit Monoclonal Antibody (058)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human Coagulation Factor X/F10.

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by excision of the tripeptide RKR. The two chains are connected by disulfide bonds; the light chain contains two EGF-like domains, and the heavy chain contains the catalytic domain homologous to other hemostatic serine proteases.

The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway). The activated factor converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.

Mutations in this gene can result in factor X deficiency, a hemorrhagic condition of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.