Thermo Fisher Scientific IL17RA Recombinant Rabbit Monoclonal Antibody (012)

Applications

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Human IL17RA/CD217.

Target Information

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes and induces maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor are implicated in inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA cause familial candidiasis type 5 (CANDF5), a rare disorder characterized by altered immune responses and impaired fungal clearance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.