Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1B12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7 K MWCO, 0.5 mL, Product #89882).

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region often reduced to homozygosity in small-cell lung cancer (SCLC), where expression is frequently reduced or undetectable. The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a zinc-binding enzyme family.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing produces multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.