Thermo Fisher Scientific ATXN10/SCA10 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ATXN10 (residues 425–475). Suitable for Western blot and immunoprecipitation. Supplied as liquid, unconjugated form at 0.20 mg/mL. Recommended storage at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of human Ataxin 10 (spinocerebellar ataxia 10) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying signs from other components of the nervous system.
A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three groups based on associated symptoms such as brainstem signs or retinopathy:
- ADCA I: Presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia
- ADCA II: Presence of retinopathy
- ADCA III: Absence of associated signs
Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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