Thermo Fisher Scientific ATXN10/SCA10 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying signs from other components of the nervous system.
A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three groups based on associated symptoms such as brainstem signs or retinopathy:

1. ADCA I: Presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia
2. ADCA II: Presence of retinopathy
3. ADCA III: Absence of associated signs

Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.